Hair loss is multifactorial. Antiandrogens are inconsistent in clinical results. Instead of fighting hair loss, we focus on strengthening the hair roots and promoting better hair growth. The article lists non-androgenic causes, enlists foods to be added and avoided for good hair growth, and provides scientific evidence for role of nutrients in hair loss management. New process of autophagy conceals clinical detection of low nutrient levels through lab tests. It is experimentally proven that DHT causes accumulation of ROS which in turn releases TGF ß1 leading to miniaturization, and this action can be successfully blocked by the use of antioxidants. Changing food preferences and decreasing nutritive value of the foods make it necessary to have supplements. Too many supplements consumed together reduce the absorption and efficiency of one another. Therefore, a low-dose once in 3 days cyclical vitamin therapy has been proposed. Nutritional correction ensures wellness, good health, and good hair growth without the fear of side effects.
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women. J Am Acad Dermatol 1996; 35: 899-906.
24. Ellis JA, Stebbing M, Harrap SB. Genetic Analysis of male pattern baldness and the 5
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... In this regard, there is an increasing interest in nonhormonal factors that play a role in AGA pathogenesis and their relationship with hormonal status [6]. In particular, micronutrients (trace elements, vitamins, and essential amino acids), a number of which have shown a positive effect on the growth and strengthening of hair roots capture the attention of researchers [7][8][9][10][11]. The regular use of food supplements, a topical L-carnitine tartrate, zinc, niacin, branched chain amino acids, and biotin treatment, led to a decrease in the rate of hair loss and an increase in the anagen/telogen ratio in individuals with AGA [12]. ...
- Irina N. Kondrakhina
-
![Dmitry Verbenko]()
- Alexander M. Zatevalov
- A. A. Kubanov
Androgenetic alopecia (AGA) is the most common variant of male pattern baldness in which occurrence and development of multiple genetic, hormonal, and metabolic factors are involved. We aimed to estimate plasma element content (Mg, Ca, Zn, Cu, Se, Fe), vitamin status (B12, D, E, and folic acid) in patients with AGA using direct colorimetric tests or atomic absorption spectrometry, and the influence of these parameters in the formation of various hair loss patterns. The study included 50 patients with I–IV stages of AGA divided into two groups with normal and high levels of dihydrotestosterone compared with 25 healthy individuals. The presence of two patterns of pathological hair loss in the androgen-dependent (parietal) and androgen-independent (occipital) areas of the scalp was confirmed. It was shown that all patients with AGA have a deficiency of elements (Zn, Cu, Mg, Se) and vitamins (B12, E, D, folic acid). However, the hair loss rate was not due to their content. А positive interrelation between quantitative trichogram parameters in the occipital region and iron metabolism in pairs "hair density vs Fe" and "hair diameter vs ferritin" was shown. In turn, in the parietal region, an inverse correlation of hair diameter with plasma Cu level was found, the most pronouncing in patients with high levels of dihydrotestosterone. The obtained results indicate the importance of multiple micronutrient deficiencies in the AGA occurrence accompanied by the existence of two different hair loss patterns, differently related to the content of certain trace elements and androgens in the blood.
-
![Rajendrasingh Rajput]()
Young patients recently shifted to metro cities are presenting with prickling in the scalp, itching, dandruff, oily scalp and pain in the hair roots. Various studies have identified this as 'Sensitive Scalp Syndrome' resulting from exposure to increasing levels of air pollution including particulate matter, dust, smoke, nickel, lead and arsenic, sulfur dioxide nitrogen dioxide, ammonia and polycyclic aromatic hydrocarbons (PAH) which settle on the scalp and hair. Indoor air conditioned environments cause volatile organic compounds (VOC) released from various sources to settle on the scalp. The pollutants migrate into the dermis, transepidermally and through the hair follicle conduit, leading to oxidative stress and hair loss. We have used antioxidants, regular hair wash, Ethylenediaminetetraacetic acid (EDTA) shampoo, and application of coconut oil to provide protection the hair and counter the effects of pollution. In this review, we have evaluated the causes, clinical presentation, mechanism of hair loss due to pollution and discussed the the management of hair loss due to air pollution (HDP). Hair loss due to pollution can coexist with or mimic androgenic alopecia. It requires careful history and trichoscopic evaluation to identify and advice a planned hair care program. Patients uniformly show an encouraging response within 6 - 8 weeks of following the hair care regimen.
-
![Rajendrasingh Rajput]()
Abstract: Finasteride 0.2 mg per day is nearly as effective as 1 mg per day. Long term side effects of finasteride may result from cumulative effect of long term, regular, daily dose. In this study we have compared the results of finasteride 1mg once in three days with daily use of finasteride 1mg with a two year follow up. The low dose finasteride group also received low dose once in three days supplements of different nutrients in synergistic combinations on different days of the week, following a once in a three day cycle. The female groups received minoxidil and compared with minoxidil plus low dose supplements. Faster and better improvement was recorded with Folliscopic counts of hair density and caliber in men and women beginning as early as two months. Average DHT (dihydrotestosterone) suppression and clinical benefit with finasteride once in three days was as good as using it every day. Each dose of finasteride was completely washed out of the system in three days before administering the next dose, thus each dose behaved as a single dose preventing the possibility of long term side effects. The use of low dose nutritional supplements provided earlier and better results when followed before and after hair transplant procedures as well. Patients reported improvement with a self assessment questionnaire.
- Izabela Urysiak-Czubatka
- M.L. Kmieć
- G. Broniarczyk-Dyła
Introduction: Androgenetic alopecia (AGA) is the most common form of hair loss. Clinically observed hair loss is due to the continuous miniaturization of affected hair follicles. Genetic factors and androgenic factors especially dihydrotestosterone (DHT), which is a testosterone tissue metabolite, play major roles in the pathogenesis of AGA. However, expert opinions about the usefulness of DHT in the diagnosis of this type of alopecia are divided. Aim: To evaluate the usefulness of DHT level in patients with androgenetic alopecia compared with the control group. Material and methods: The study comprised 49 subjects: 19 women and 9 men with androgenetic alopecia. The control group consisted of 17 healthy women and 4 men without hair loss. Results: Increased serum concentrations of DHT were observed in patients with androgenetic alopecia (17 women, 5 men), but also in the control group. The differences in mean values of DHT were not significant according to the types of alopecia and the control group. Increased serum concentrations of DHT were not correlated with the advance of alopecia. Conclusions: Dihydrotestosterone is the most influential androgen and seems to play a very important role in the pathogenesis of androgenetic alopecia. Based on the results of our study and others, the most important factors would appear to be the genetically-determined sensitivity of the follicles to DHT and their different reactions to androgen concentration.
Objective: The role of the oxidative stress in alopecia areata (AA) has been studied by several researchers in a few studies with conflicting results. These results suggested that lipid peroxidation and alterations in the oxidant-antioxidant enzymatic system may play a role in the pathogenesis of AA. Therefore, we aimed to examine the possible associations between the MnSOD Ala-9Val and GPx1 Pro 198 Leu polymorphisms and AA susceptibility and disease progression in Turkish population. Methods: The study group consisted of 119 unrelated patients with AA and 104 unrelated healthy controls with no scalp lesions in their personal history or on clinical examination. Genotyping was performed to identify MnSOD Ala-9Val and GPx1 Pro 198 Leu polymorphisms by a method based on PCR amplification and detection of polymorphisms with hybridization probes labeled with fluorescent dyes. Genotype and allele frequencies were compared between patients with AA and healthy control subjects. Results: There was no significant difference between the MnSOD Ala-9Val SNP genotype distributions and allele frequencies of the AA patients and the control group (P=0.168 and P=0.820, respectively). There was not any association between clinical and demographical features of the study patients with AA and MnSOD Ala-9Val and GPx1 Pro 198 Leu polymorphism genotypes except gender. Conclusions: This study is unique since an investigation to reveal the possible associations between the MnSOD Ala-9Val and GPx1 Pro 198 Leu polymorphisms and AA susceptibility and in Turkish population.
- I.A. Sadek
- H.M. Ismail
- H.N. Sallam
- M. Salem
An analysis of residues from anabolic agents found in commercially available meat and poultry was undertaken in Alexandria, Egypt. This study shows that beef meat samples purchased from government cooperative supermarkets exhibit higher levels of the synthetic growth promoter, trenbolone acetate, than meat from private butchers; however, estrogen levels were much higher in chicken obtained from private growers. A comparison of different cooking methods was conducted on the chicken samples; boiling without skin is recommended to reduce the consumer's intake of hormonal residues.
- RonaldL Rizer
- ThomasJ Stephens
- JamesH Herndon
-
![Glynis Ablon]()
Introduction: Since skin and hair quality are potent vitality signals, and hair growth deficiency can cause significant psychological morbidity. In addition to clearly-defined hair loss disorders, milder forms of hair thinning or hair loss appear to be increasingly common, with a suggestion that sub-optimal diets and stressful lifestyles may be involved. Methods: Here we assess the value of a dietary marine-extract based dietary supplement in premenopausal women with subclinical hair thinning or hair loss conditions. This multi-site, randomized double-blind, placebo-controlled clinical trial was conducted with impact on hair shedding rate and hair fiber diameter (assessed by phototrichogram) as primary end points upon consumption of the oral supplement compared to a placebo. A total of 96 eligible female subjects were enrolled aged 21-55 years of age from Asian, Caucasian, and Hispanic ethnic backgrounds. Results: This study showed that hair shedding was significantly reduced in the first 3-6 months of daily consumption of the oral supplement. Moreover, phototrichogram image analysis revealed a statistically significant increase in the mean vellus-like hair diameter after 6 months of supplement consumption, when compared to the mean vellus-like hair diameters measured at baseline. Discussion: These results support the view that a nutritional supplement approach may be useful for women in this age group to deal with subclinical hair thinning or hair loss conditions, and those components of this marine extract-based oral supplement may be a useful adjunct.
- HarmeetSingh Banger
- SureshKumar Malhotra
- Sohan Singh
-
![Mridula Mahajan]()
Background: Androgenic alopecia (AGA) is a common cosmetically and psychosocially distressing condition. High androgen level contributes to the development of atherosclerosis, thrombosis leading to hypertension and hypercholesterolemia. Objectives: To study the clinico-epidemiological profile of AGA and the presence of metabolic syndrome (MetS) and carotid artery atherosclerosis in male patients with early onset AGA as compared to controls. Materials and methods: In this case-control study, 100 male patients of age 18-35 years with AGA and an equal number of age-matched healthy controls attending skin and STD OPD were included. Assessment of the degree of hair loss, evaluation of MetS and carotid artery color Doppler for the atherosclerotic plaque was done in all patients. Results: Statistically significant number of patients with early onset AGA 22/100 (22%) (P < 0.05) fulfilled the criteria for MetS compared to 8/100 (8%) in the control group. There were statistically significant differences in mean values of waist circumference, serum triglycerides, serum cholesterol, systolic blood pressure, diastolic blood pressure, fasting glucose concentration, and very low-density lipoprotein (LDL). However, no significant differences were observed in the mean values of high-density lipoprotein cholesterol and LDL cholesterol. The atherosclerotic plaque was found in two patients of the study group, and no plaque was found in control patients. Conclusion: We suggest that all men with AGA should be thoroughly investigated, and lifestyle changes should be started in the early period of life so as to reduce the risk of various problems associated with MetS. AGA can be considered as an early marker for MetS.
- Detlef K. Goette
Nine patients experienced profuse hair loss two to five months after starting a vigorous weight reduction program resulting in weight loss of 11.7 to 24.75 kg. Telogen counts of 25% to 50% were observed. Regrowth of hair occurred within several months. Three patients had experienced hair loss closely following a successful weight reduction program on several occasions. Rigorous caloric restriction with subsequent inadequate energy supply of the hair matrix is thought to be the cause for the precipitation of the telogen effluvium of the crash dieter. (JAMA 235:2622-2623, 1976)
Source: https://www.researchgate.net/publication/325014754_Nutritional_Correction_for_Hair_Loss_Thinning_of_Hair_and_Achieving_New_Hair_Regrowth
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